Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease
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چکیده
منابع مشابه
Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease.
Notch signaling plays a critical role in cell fate determination in many developmental systems, including the hematopoietic system. We and others have recently cloned a novel Notch ligand called Delta4. In this study, we show the effect of retrovirus-mediated ectopic expression of Delta4 in hematopoietic cells. Lethally irradiated mice transplanted with bone marrow cells expressing Delta4 initi...
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ژورنال
عنوان ژورنال: Blood
سال: 2002
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v100.6.2046.h81802002046_2046_2055